Muscadines are highly researched and widely consumed in the U.S. More than 100 preclinical and clinical studies have been published on muscadines! And, thousands more studies have evaluated the potential health benefits of the antioxidant molecules found in muscadine.

Muscadine nutrients are in food-bound form, which means they’re bioavailable and better absorbed into cells. And studies show muscadines are more effective at quenching free radicals compared to isolated antioxidants like vitamin C and quercetin at quenching free radicals. 

 In addition to the high content of antioxidants in Muscadine grape products and extracts, compounds in Muscadine also stimulate the body’s own antioxidant protection mechanisms.

Muscadines’ whole-food synergy was confirmed when studies found it may stimulate both types of antioxidant defenses in the body — exogenous and endogenous. (Most antioxidants only support a limited number of antioxidant pathways).The polyphenol-preparation from Muscadine grape was tested in a blend with chemically pure resveratrol. The blend containing Muscadine polyphenols reduced the inflammatory response to a test meal, in part via the induction of genes involved in production of antioxidant enzymes, called “Antioxidant Response Elements (ARE)”, These include genes, such as Nrf-2, that regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation,

Muscadine grape polyphenols contribute to the regulation of our genes to increase our body’s own antioxidant protection, beyond the antioxidants in the grape itself.