Muscadines are highly researched and widely consumed in the U.S. More than 100 preclinical and clinical studies have been published on muscadines! And, thousands more studies have evaluated the potential health benefits of the antioxidant molecules found in muscadine.

Muscadine nutrients are in food-bound form, which means they’re bioavailable and better absorbed into cells. And studies show muscadines are more effective at quenching free radicals compared to isolated antioxidants like vitamin C and quercetin at quenching free radicals. 

 In addition to the high content of antioxidants in Muscadine grape products and extracts, compounds in Muscadine also stimulate the body’s own antioxidant protection mechanisms.

Muscadines’ whole-food synergy was confirmed when studies found it may stimulate both types of antioxidant defenses in the body — exogenous and endogenous. (Most antioxidants only support a limited number of antioxidant pathways).The polyphenol-preparation from Muscadine grape was tested in a blend with chemically pure resveratrol. The blend containing Muscadine polyphenols reduced the inflammatory response to a test meal, in part via the induction of genes involved in production of antioxidant enzymes, called “Antioxidant Response Elements (ARE)”, These include genes, such as Nrf-2, that regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation,

Muscadine grape polyphenols contribute to the regulation of our genes to increase our body’s own antioxidant protection, beyond the antioxidants in the grape itself.

The various health benefits of muscadines have been studied in clinical and preclinical trials. Some of the areas of health studied include:

  • Potent Antioxidant; Supports Body’s Antioxidant Defense
  • Energy and Mitochondrial Biogenesis
  • Healthy Aging
  • Cardiovascular Support & Healthy Blood Pressure
  • Men’s Health & Prostate Health
  • Healthy Metabolism
  • Brain and Cognitive Health
  • Sports Nutrition
  • Liver Support, Detoxification
  • Inflammation


For these reasons, Muscadines, also known as “Super Grapes” are expected to be the ultimate anti-aging food for this century!

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