Chronic inflammation is at the core of many health issues, including cardiovascular disease, metabolic syndrome and diabetes, degenerative joint and muscular diseases, pain perception, cognitive decline, mental health problems including depression, and the initiation and progression of cancer.

The many anti-inflammatory properties are fundamental for the health supportive activities of muscadine products. The strong anti-inflammatory effects of muscadine grape have been documented in a broad number of experimental and clinical models.

Examples include:

• Reduction of inflammatory behavior at the cellular level:

• Reduced production of Superoxide;

• Reduced production of highly inflammatory cytokines IL-6 and TNF-a

• Reduction of experimentally induced tissue inflammation in animals,

• Reduced inflammation of the eye, and protection from tissue damage following inflammation of the eye (mouse model);

• Reduction of glucose-induced inflammation of human vascular cells;

• The biological effect of some antioxidant compounds in Muscadine grape are enhanced by the digestive process, including fermentation by gut bacteria.

  Overall, these experimental models suggest that the anti-inflammatory support from Muscadine grape-based products are relevant for cardiovascular, metabolic, neurological and brain health, and long-term protection of overall health.