Muscadine Whole-Food Synergy – MUSCADINES.COM

Polyphenols from foods are widely studied to support the function of brain, heart, liver, joints, muscle recovery, and other organs. As antioxidants, they support the body’s cellular function and recovery from normal metabolism, and reduce oxidative stress and inflammation associated with many disease states.

Muscadine’s polyphenols are unique because they contain both resveratrol and ellagic acid, two antioxidants that are found in red wine, pomegranate and berries. Resveratrol is a well-researched antioxidant that is shown to extend lifespan in animals, act on mitochondria to improve metabolic function, and possess a number of beneficial activities when consumed. Ellagic acid and gallic acid, plus the polyphenolic tannins from which they are derived during ripening and processing, are potent antioxidants that have metabolic, anti-inflammatory and anti-cancer activities.

Muscadine also contains flavonoids such as anthocyanins and quercetin, which lend a purple-red or yellow hue to the fruit, respectively. Catechin flavonoids such as epicatechin, epicatechin gallate, and proanthocyanidin tannins are also found in the fruit, mainly in the seed.

Primary muscadine polyphenols include:

Resveratrol, a well-researched antioxidant that is shown to extend lifespan in animals, acts on mitochondria to improve metabolic function, and possess a number of beneficial activities when consumed.
Ellagitannins, including ellagic acid and gallic acid, are potent antioxidants that have metabolic, anti-inflammatory and anti-cancer activities.
Muscadine also contains flavonoids such as anthocyanins and quercetin, which lend a purple-red or yellow hue to the fruit, respectively.
Catechin flavonoids such as epicatechin, epicatechin gallate, and oligomeric proanthocyanidin tannins are also found in the fruit, mainly in the seed.

Muscadine and blueberry phenolics were found to have the same activity at the same concentrations on cancer cells. Muscadine and resveratrol both exhibit anticancer activity in ways that are both similar and different. In contrast to muscadine skin extract, resveratrol did not induce apoptosis but arrested prostate cancer cells at the G1-S phase transition. Although muscadine skin contains resveratrol, researchers discovered unique properties of muscadine skin, indicative of multiple supportive antioxidant activities in the body.